Related Experiment Video
Updated: Nov 29, 2025
05:17
Author Spotlight: Scope of LE-ULBD as a Safe, Effective, and Minimally Invasive Approach to Treat Lumbar Spinal Stenosis
Published on: February 9, 2024
994
Bilateral pedal edema associated with lurasidone: a case report
Chun-Yi Su1, Wei-Tse Hsu1, Ching-Hua Lin1,2
1Kaohsiung Municipal Kai-Syuan Psychiatric Hospital.
International Clinical Psychopharmacology
|November 24, 2020
Summary
Lurasidone, an atypical antipsychotic, may cause pedal edema. Discontinuation of lurasidone resolved the swelling, suggesting a causal link and potential impact on patient adherence.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Lurasidone is an atypical antipsychotic approved for schizophrenia and bipolar depression.
- The potential for lurasidone to cause pedal edema is not well-documented.
Observation:
- A 55-year-old female with bipolar I disorder developed bilateral lower leg and ankle swelling.
- This occurred after initiating lurasidone in combination with escitalopram for a depressive episode.
Findings:
- Discontinuation of lurasidone led to the complete resolution of pedal edema.
- The temporal relationship suggests lurasidone as a potential cause of the observed edema.
Implications:
- Lurasidone may induce pedal edema in susceptible patients.
- Clinicians should monitor for edema when prescribing lurasidone, as it may affect treatment adherence.
