Related Experiment Video
Updated: Nov 29, 2025
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
Published on: February 4, 2022
A serial SPECT-CT study in a celiac disease patient with cerebellar ataxia and psychiatric symptoms
Juliana J Schmidt1, Guilherme J Schmidt2, Julio C Tolentino2
1Department of Neurology, Federal University of the State of Rio de Janeiro, Mariz and Barros street, 775, Tijuca, Rio de Janeiro, RJ, 202709-001, Brazil. julianaschmidtjaneiro@gmail.com.
Abstract:
Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten and related prolamins in genetically predisposed individuals. Here, we described a case of a 31-year-old Caucasian woman who exhibited cerebellar and psychiatric dysfunctions. The patient underwent single-photon emission computed tomography (SPECT-CT) before and after a gluten-free diet (GFD). There was an improvement in cerebellar perfusion accompanied by a remission of cerebellar manifestations. The maintenance of the psychiatric manifestations was related to the persistence of the hypoperfusion in the frontal lobes. The patient's psychiatric symptoms did not change after 4 months under a GFD in the hospital. To our knowledge, this is the first case that shows the relationship between improvement in cerebellar perfusion and remission of cerebellar clinical manifestations in a CD patient under a GFD.
