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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: Nov 28, 2025

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

HumiR: Web Services, Tools and Databases for Exploring Human microRNA Data.

Jeffrey Solomon¹, Fabian Kern¹, Tobias Fehlmann¹

¹Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

|November 25, 2020

Summary

This summary is machine-generated.

HumiR offers a unified web platform for human small non-coding RNA research tools. This resource aids researchers in selecting appropriate tools for tasks like microRNA analysis and expression profiling.

Keywords:

bioinformatics microRNAs non-coding RNA web servers

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Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

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A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

Computational tools and databases are crucial for small non-coding RNA research, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and circular RNAs (circRNAs).
Existing tools often focus on species-independent analyses, yet a consolidated resource for human-specific small non-coding RNAs is lacking.
Interoperability between various tools for miRNA analysis, target prediction, and expression profiling remains a challenge.

Purpose of the Study:

To present HumiR, a unified web presence integrating tools for human small non-coding RNA research.
To facilitate the selection of appropriate computational tools for diverse miRNA-related research tasks.
To establish a foundational step towards a comprehensive knowledge base for human small non-coding RNA research.

Main Methods:

Development and integration of human-specific tools for miRNA analysis, including quantification and prediction.
Compilation of databases for human miRNAs, their variations, and expression profiles across different tissues and cell types.
Creation of helper tools for common tasks like naming conversion and reporter assay design.

Main Results:

HumiR provides a centralized access point for a suite of human small non-coding RNA analysis tools.
The platform supports tasks such as miRNA quantification, isomiR prediction, target analysis, and expression profiling.
Demonstrated utility through a comprehensive analysis of Alzheimer's disease-associated miRNAs.

Conclusions:

HumiR enhances accessibility and usability for researchers in the human small non-coding RNA field.
The integrated platform streamlines workflows and aids in tool selection for specific research questions.
HumiR represents a significant advancement towards a unified knowledge base for human small non-coding RNA research.