Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"It is the foundation for the child": a qualitative study examining caregiver perspectives on the Nurturing Care Framework in Kenya and Botswana.

BMJ public health·2026
Same author

A descriptive analysis of social determinant of health needs and medication therapy problems in a comprehensive medication management population.

Journal of the American Pharmacists Association : JAPhA·2026
Same author

[Medical care effect in assisted reproductive technology on couple's sexuality].

Gynecologie, obstetrique, fertilite & senologie·2025
Same author

Understanding, Assessing, and Improving Social Health Resource Referrals in Healthcare Organizations.

Health services research·2025
Same author

Retest reliability and reliable change of community-dwelling Black/African American older adults with and without mild cognitive impairment using NIH Toolbox-Cognition Battery and Cogstate Brief Battery for laptop.

Journal of the International Neuropsychological Society : JINS·2024
Same author

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics.

Molecular systems biology·2024

Related Experiment Video

Updated: Nov 28, 2025

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
08:25

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope

Published on: April 21, 2023

1.5K

Tranexamic acid and traumatic brain injuries.

Katarina Sanford1, Sarah Garcia

  • 1At the time this article was written, Katarina Sanford was a student in the PA program at the University of St. Francis in Albuquerque, N.M. Sarah Garcia is pharmacotherapeutics course director at the University of St. Francis. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|November 25, 2020
PubMed
Summary

Tranexamic acid (TXA) reduces mortality in mild to moderate traumatic brain injuries with intracranial bleeding. However, trial limitations mean TXA is not yet the definitive treatment.

More Related Videos

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.1K

Related Experiment Videos

Last Updated: Nov 28, 2025

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
08:25

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope

Published on: April 21, 2023

1.5K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.1K

Area of Science:

  • Trauma surgery
  • Emergency medicine
  • Neurocritical care

Background:

  • Traumatic brain injury (TBI) is a leading cause of death and disability worldwide.
  • Intracranial bleeding is a common and serious complication of TBI.
  • Antifibrinolytic agents like tranexamic acid (TXA) are used to control bleeding.

Purpose of the Study:

  • To evaluate the efficacy of tranexamic acid (TXA) in reducing mortality in patients with traumatic intracranial bleeding.
  • To determine if TXA is a suitable treatment for head injuries.

Main Methods:

  • The CRASH-3 trial was a randomized controlled trial.
  • Involved patients with intracranial bleeding secondary to traumatic brain injury.
  • Administered TXA to assess its impact on mortality.

Main Results:

  • Tranexamic acid (TXA) demonstrated a reduction in mortality among patients with mild to moderate head injuries.
  • The study identified potential benefits of TXA in this patient population.

Conclusions:

  • TXA shows promise in reducing mortality for specific TBI patients.
  • The CRASH-3 trial's limitations preclude classifying TXA as the gold standard treatment currently.
  • Further research may be needed to fully establish TXA's role in TBI management.