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Occult olfactory neuroblastoma presenting with multiple bone metastases: a case report
Olfactory neuroblastoma (ONB), a rare nasal cavity cancer, can present as bone pain, mimicking multiple myeloma. Early positron emission computed tomography (PET) scans are crucial for diagnosing occult ONB and guiding treatment.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Olfactory neuroblastoma (ONB) is a rare malignant tumor originating in the nasal cavity.
- ONB often presents with inconspicuous local symptoms, leading to delayed diagnosis and misdiagnosis.
Observation:
- A 47-year-old female presented with multiple ostealgia, initially misdiagnosed as multiple myeloma.
- Bone marrow examination suggested neuroectodermal origin, prompting further investigation.
Findings:
- Positron emission computed tomography (PET) scan identified the primary nasal cavity lesion.
- Histopathological tests confirmed olfactory neuroblastoma.
- Metronomic chemotherapy resulted in significant pain relief and disease stabilization.
Implications:
- Prompt PET scans are vital for identifying occult primary tumors in metastatic disease cases.
- This approach aids in the early diagnosis of rare malignancies like ONB.
- Timely diagnosis and treatment can improve patient outcomes and manage symptoms effectively.
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