Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation, Identification and Pathogenicity Analysis of Proteus mirabilis in Cynomolgus Monkey From Yunnan, China.

Veterinary medicine and science·2026
Same author

Molecular Identification and Drug Sensitivity Test of <i>Acinetobacter lwoffii</i> from Cynomolgus Monkey with Peritonitis.

Veterinary sciences·2026
Same author

Squamous Cell Carcinoma of the Tongue in Captive Rhesus Monkeys (Macaca mulatta).

Journal of medical primatology·2025
Same author

[Biological Differences between EGFR ex19del and ex21L858R-Preclinical Models Using an Engineered Pair of Isogenic NSCLC Cell Lines with CRISPR Engineering].

Gan to kagaku ryoho. Cancer & chemotherapy·2025
Same author

Isolation, Identification, and Drug Sensitivity Test of <i>Pseudomonas aeruginosa</i> from Cynomolgus Monkey (<i>Macaca fascicularis</i>).

Veterinary sciences·2025
Same author

Production of live monkeys and their genetically matched embryonic stem cells from single embryos.

Nature communications·2025

Related Experiment Video

Updated: Jun 13, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

18.8K

Diffuse Large B-Cell Lymphoma in a Cynomolgus Monkey.

Heling Li1,2, Long Zhang3, Zhigang Chen1,2

  • 1State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.

Journal of Medical Primatology
|September 9, 2024
PubMed
Summary

A cynomolgus monkey developed diffuse large B-cell lymphoma (DLBCL), the first reported case with a mandible mass invading the paranasal sinus. This finding aids in diagnosing and treating DLBCL in non-human primates.

Keywords:
cynomolgus monkeydiffuse large B‐cell lymphomamandibleparanasal sinus

More Related Videos

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.1K
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
06:25

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Published on: December 23, 2016

9.2K

Related Experiment Videos

Last Updated: Jun 13, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

18.8K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.1K
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
06:25

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Published on: December 23, 2016

9.2K

Area of Science:

  • Veterinary Pathology
  • Primate Oncology
  • Comparative Oncology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is a significant hematologic malignancy.
  • Non-human primates (NHPs) serve as valuable models for human diseases, including cancers.
  • Understanding NHP-specific disease presentations is crucial for research and clinical care.

Observation:

  • A 17-year-old captive male cynomolgus monkey (Macaca fascicularis) presented with a diffuse large B-cell lymphoma.
  • The lymphoma manifested as a mandible mass, uniquely invading the paranasal sinus.
  • Microscopic examination revealed a highly malignant neoplasm.

Findings:

  • Immunohistochemical staining confirmed strong positive expression of CD20, a B-cell marker.
  • The tumor exhibited characteristics consistent with diffuse large B-cell lymphoma.

Implications:

  • This case represents the first reported instance of DLBCL with mandible mass and paranasal sinus invasion in cynomolgus monkeys.
  • The findings provide valuable insights for diagnosing and developing therapeutic strategies for DLBCL in NHPs.
  • This study contributes to the broader understanding of lymphoma in non-human primates, aiding comparative oncology research.