Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

6.0K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.0K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

66.1K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
66.1K
The Cell Cycle Control System01:28

The Cell Cycle Control System

4.7K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
4.7K
The Cell Cycle Control System02:11

The Cell Cycle Control System

13.4K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
13.4K
Redox Reactions01:27

Redox Reactions

574
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
574
Redox Reactions01:24

Redox Reactions

57.7K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
57.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Legacy of Mentorship: A Tribute to Lewis Cantley.

Cancer discovery·2026
Same author

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B.

bioRxiv : the preprint server for biology·2026
Same author

Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth.

Cancer discovery·2025
Same author

Pseudouridine residues as substrates for serum ribonucleases.

RNA (New York, N.Y.)·2025
Same author

Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth.

Cancer discovery·2025
Same author

A bacterial immunity protein directly senses two disparate phage proteins.

Nature·2024
Same journal

Mutation detection in women diagnosed with endometrial cancer: a next-generation sequencing analysis.

Molecular & cellular oncology·2026
Same journal

Evolutionary perspectives on endometrial cancer: antagonistic pleiotropy.

Molecular & cellular oncology·2026
Same journal

mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting.

Molecular & cellular oncology·2026
Same journal

Exploration of the diagnostic and therapeutic potential of the nucleocytoplasmic shuttling protein TMUB1 by inducing G0/G1 cell cycle arrest in ovarian cancer.

Molecular & cellular oncology·2026
Same journal

The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors.

Molecular & cellular oncology·2026
Same journal

Lactylation-related genes signature panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization.

Molecular & cellular oncology·2026
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

Cellular Redox Profiling Using High-content Microscopy
11:37

Cellular Redox Profiling Using High-content Microscopy

Published on: May 14, 2017

11.3K

Are redox changes a critical switch for mitotic progression?

Daniel C Lim1, Vladimir Joukov2, Michael B Yaffe1,3

  • 1MIT Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Molecular & Cellular Oncology
|November 25, 2020
PubMed
Summary
This summary is machine-generated.

Oxidative stress during cell division activates Aurora A kinase (AURKA) by modifying a key cysteine residue. This discovery may lead to new cancer therapies targeting this redox-sensitive mechanism.

Keywords:
AURKAkinase activationmitosismitotic kinaseredox regulation

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.0K
Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.4K

Related Experiment Videos

Last Updated: Nov 28, 2025

Cellular Redox Profiling Using High-content Microscopy
11:37

Cellular Redox Profiling Using High-content Microscopy

Published on: May 14, 2017

11.3K
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.0K
Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells
12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.4K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Cell division involves dynamic redox changes, leading to increased protein oxidation in mitotic cells.
  • Aurora A kinase (AURKA) plays a critical role in cell cycle regulation and mitosis.

Purpose of the Study:

  • To investigate the impact of redox modifications on Aurora A kinase (AURKA) activity during mitosis.
  • To explore the potential of targeting redox-sensitive cysteine residues in AURKA for cancer therapy.

Main Methods:

  • Analysis of redox-dependent modifications on AURKA.
  • Investigating the functional consequences of cysteine oxidation on AURKA activation during mitosis.

Main Results:

  • Oxidative modification of a conserved cysteine residue in AURKA promotes its activation during mitosis.
  • Identified a specific redox-sensitive cysteine residue within AURKA crucial for its mitotic function.

Conclusions:

  • Cell-cycle dependent redox changes directly influence AURKA activity through cysteine oxidation.
  • Targeting redox-sensitive cysteines in AURKA presents a promising strategy for developing novel anti-cancer agents with enhanced efficacy.