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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

377
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
377
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

507
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
507
Sleep Apnea01:21

Sleep Apnea

332
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
332
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

408
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
408
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

274
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
274
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

466
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
466

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Related Experiment Video

Updated: Nov 28, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Association Between Obstructive Sleep Apnea and Barrett's Esophagus: A Systematic Review and Meta-Analysis.

Yousef Elfanagely1, Amporn Atsawarungruangkit2, James Scharfen3

  • 1Department of Internal Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy Street, Jane Brown Ground, Suite 0100, Providence, RI, USA. yousef_elfanagely@brown.edu.

Digestive Diseases and Sciences
|November 25, 2020
PubMed
Summary

Patients with Barrett's esophagus have a significantly increased risk of obstructive sleep apnea (OSA). This meta-analysis highlights a strong association between these two conditions, suggesting further research is needed.

Keywords:
Barrett’s esophagusObstructive sleep apnea

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Area of Science:

  • Gastroenterology
  • Pulmonology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is linked to gastroesophageal reflux disease.
  • The independent association between OSA and Barrett's esophagus requires further clarification.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies evaluating the association between OSA and Barrett's esophagus.

Main Methods:

  • A comprehensive search of multiple electronic databases (MEDLINE, Embase, Web of Science, CINAHL, Cochrane) was conducted.
  • Inclusion criteria focused on observational studies (retrospective, case-control) in adult subjects assessing the OSA-Barrett's esophagus link.
  • A random-effects model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CI).

Main Results:

  • Six studies with 2333 subjects were included in the meta-analysis.
  • A significantly increased risk of OSA, high-risk OSA, and OSA symptoms was observed in patients with Barrett's esophagus (OR 2.19, 95% CI 1.53-3.15).
  • Subgroup analysis of definite OSA and Barrett's esophagus confirmed a significant association (OR 2.59, 95% CI 1.39-4.84).

Conclusions:

  • This meta-analysis demonstrates a significantly elevated risk of OSA in individuals with Barrett's esophagus.
  • Further research is essential to elucidate the underlying pathophysiology and clinical significance of this association.