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Related Experiment Video

Updated: Nov 28, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Summation anaphylaxis: A challenging diagnosis.

Mauro Calvani¹, Caterina Anania², Barbara Cuomo³

¹UOC di Pediatria, Azienda Ospedaliera S. Camillo Forlanini, Roma, Italy.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology

|November 25, 2020

Summary

Summation anaphylaxis (SA) occurs when multiple triggers, like food and exercise, combine to cause a severe allergic reaction. Identifying these cofactors is crucial for diagnosing rare cases of anaphylaxis.

Keywords:

anaphylaxis cofactors food-dependent exercise-induced anaphylaxis summation anaphylaxis

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Last Updated: Nov 28, 2025

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Published on: October 25, 2018

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

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Published on: September 14, 2018

Area of Science:

Allergy and Immunology
Clinical Medicine

Background:

Anaphylaxis is a severe allergic reaction with various triggers, including food, insect venom, drugs, and exercise.
Summation anaphylaxis (SA) is a rare condition where a single trigger is tolerated, but a combination of triggers causes a reaction.

Purpose of the Study:

To define summation anaphylaxis (SA) and its associated cofactors.
To highlight the importance of identifying cofactors in diagnosing unexplained anaphylaxis.

Main Methods:

Literature review and clinical case analysis.
Detailed patient history focusing on potential cofactors.

Main Results:

Food-dependent exercise-induced anaphylaxis is a well-known form of SA.
Other cofactors include NSAIDs, alcohol, infections, temperature changes, and menstrual cycle.
SA can explain idiopathic anaphylaxis and apparent tolerance loss.

Conclusions:

SA is a critical concept for understanding complex allergic reactions.
Thorough clinical history, including cofactors, is essential for diagnosing SA.
Recognizing SA can prevent misdiagnosis of idiopathic anaphylaxis or food allergy.