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COVID-19 endocrinopathy with hindsight from SARS
Narasimhan Kothandaraman1, Anantharaj Rengaraj2, Bo Xue3,4
1Singapore Institute for Clinical Sciences, Brenner Centre for Molecular Medicine, Agency for Science, Technology and Research (A*STAR), Singapore.
American Journal of Physiology. Endocrinology and Metabolism
|November 25, 2020
Summary
The COVID-19 pandemic impacts the endocrine system, causing issues like new diabetes, hypocortisolism, and reproductive problems. Understanding these coronavirus-associated endocrinopathies aids clinical care.
Area of Science:
- Endocrinology
- Infectious Diseases
- Virology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, primarily affects the respiratory system but also causes extrapulmonary complications.
- Emerging evidence highlights the significant impact of coronaviruses on the endocrine system, contributing to disease severity and mortality.
Purpose of the Study:
- To summarize the impact of SARS-CoV and SARS-CoV-2 on the endocrine system.
- To elucidate the nature of coronavirus-associated endocrinopathies.
- To provide clinicians with insights into endocrine dysfunctions in COVID-19 patients.
Main Methods:
- Literature review and synthesis of current data on SARS-CoV and SARS-CoV-2.
- Analysis of reported endocrine manifestations associated with COVID-19.
- Categorization of endocrine dysfunctions including diabetes, hypocortisolism, thyroid, and reproductive issues.
Main Results:
- SARS-CoV-2 infection is associated with new-onset diabetes mellitus.
- Hypocortisolism and thyroid hormone dysregulation are observed in COVID-19 patients.
- Reproductive system aberrations have been reported in the context of coronavirus infections.
Conclusions:
- Coronavirus infections, including COVID-19, can lead to diverse endocrine dysfunctions.
- Recognizing these endocrine manifestations is crucial for comprehensive patient management.
- Further research is needed to fully understand and address coronavirus-associated endocrinopathies.
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