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Related Experiment Video

Updated: Jun 16, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

An electronic, unsupervised patient-reported Expanded Disability Status Scale for multiple sclerosis.

Andrew R Romeo¹, William M Rowles¹, Erica S Schleimer¹

¹UCSF MS Epic Study Group.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|November 25, 2020

Summary

A new electronic tool, the ePR-EDSS, accurately measures multiple sclerosis disability. This scalable, unsupervised patient-reported outcome allows for easier research participation and clinical monitoring.

Keywords:

Multiple sclerosis disability eHealth patient-reported outcome measures

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Area of Science:

Neurology
Clinical Assessment
Digital Health

Background:

The Expanded Disability Status Scale (EDSS) is the standard for multiple sclerosis (MS) disability assessment.
Its in-person requirement limits patient participation in research and clinical evaluations.

Purpose of the Study:

To develop and validate a scalable, electronic, unsupervised patient-reported EDSS (ePR-EDSS).
To capture MS-related disability across the full spectrum of severity.

Main Methods:

136 adult MS patients were enrolled in two cohorts for preliminary testing and validation.
Patients completed the ePR-EDSS before or after a clinician's EDSS evaluation.

Main Results:

The ePR-EDSS showed high correlation (r=0.91) and agreement (kappa=0.85) with the clinician-assessed EDSS.
Agreement within 1-point was achieved in 86% of cases in the validation cohort.

Conclusions:

The ePR-EDSS is a valid and reliable measure of MS disability, correlating well with the established EDSS.
This tool facilitates longitudinal patient monitoring and broadens research participation by reducing in-person assessments.