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Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

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Updated: Nov 28, 2025

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

Published on: January 6, 2016

Database Development for Antibody Arrays.

Zhaowei Xu¹, Likun Huang¹, Sheng-Ce Tao²

¹Key Laboratory of Systems Biology, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Methods in Molecular Biology (Clifton, N.J.)

|November 25, 2020

Summary

This summary is machine-generated.

Antibody arrays generate crucial data for research and clinical use. The protein microarray database (PMD) offers standardized data management and automated analysis pipelines for antibody microarray studies.

Keywords:

Antibody array Data analysis Data archiving and Data sharing Database

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Last Updated: Nov 28, 2025

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray

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Published on: January 6, 2016

Analysis of Histone Antibody Specificity with Peptide Microarrays

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Published on: August 1, 2017

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

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Published on: September 15, 2016

Area of Science:

Biotechnology
Bioinformatics
Immunology

Background:

Antibody arrays are vital tools in biomedical research and clinical diagnostics.
Effective management and analysis of antibody array data are essential for scientific advancement.
Existing data handling methods can be fragmented, hindering reproducibility and collaboration.

Purpose of the Study:

To introduce the Protein Microarray Database (PMD) as a solution for antibody microarray data management.
To detail the framework design and platform construction of the PMD.
To highlight the integration of analysis tools within the PMD for automated data processing.

Main Methods:

Describing the architectural design of the PMD.
Detailing the technical implementation of the PMD platform.
Explaining the integration process for various array data analysis tools.

Main Results:

The PMD provides a standardized framework for managing protein microarray data.
An automated pipeline for array data analysis has been successfully developed and integrated.
The PMD facilitates efficient data archiving and sharing for antibody microarray studies.

Conclusions:

The Protein Microarray Database (PMD) offers a robust solution for antibody microarray data.
Standardized management and automated analysis enhance the utility of antibody array data.
The PMD supports the broader scientific community by enabling better data exploration and sharing.