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Microfluidic Systems for Assisted Reproductive Technologies: Advantages and Potential Applications
Russel C Sequeira1, Tracy Criswell1, Anthony Atala1
1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Tissue Engineering and Regenerative Medicine
|November 25, 2020
Summary
Microfluidic devices offer advanced solutions for assisted reproductive technology (ART), improving oocyte and embryo handling. These systems promise to revolutionize reproductive research and clinical applications by mimicking in-vivo conditions.
Area of Science:
- Biotechnology and Biomedical Engineering
- Reproductive Biology and Medicine
Background:
- Assisted reproductive technology (ART) faces challenges in efficiency, cost, and monitoring.
- Microfluidic technologies can closely replicate in-vivo physiological conditions.
Purpose of the Study:
- To review the applications of microfluidic devices in ovarian follicle development and ART.
- To discuss current and future microfluidic platforms for oocyte, sperm, and embryo handling.
Main Methods:
- Review of existing literature on microfluidic devices in reproductive science.
- Discussion of platforms for oocyte/sperm selection, fertilization, and embryo culture/monitoring.
Main Results:
- Microfluidic devices are utilized for culturing ovarian follicles and maintaining gametes.
- Platforms facilitate fertilization (IVF/ICSI) and monitoring/selection of embryos.
- Potential for integrated microfluidic systems exists, despite current limitations.
Conclusions:
- Microfluidic systems show significant potential to enhance ART and reproductive research.
- Future integration of microfluidic technologies could revolutionize reproductive physiology and toxicology studies.
- These advancements are expected to improve clinical ART outcomes and fundamental research.
