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A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch

Matthew T Eddy1, Bryan T Martin2, Kurt Wüthrich3

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Departments of Biological Sciences and Chemistry, Bridge Institute, The University of Southern California, Los Angeles, CA 90089, USA; Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.

Structure (London, England : 1993)
|November 25, 2020
PubMed

Keywords:
G protein-coupled receptorsNMR spectroscopydrug efficacypartial agonists

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