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Indole alkaloids from Ophiorrhiza cantoniensis with immunosuppressive activity
Wen-Zhe Xie1, Hui-Xiang Yang1, Zheng-Hui Li1
1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Abstract:
Three new indole alkaloids, ophiorrhines C-D (1-3), together with one known analogue, have been isolated from the plant of Ophiorrhiza cantoniensis Hace. The structures of the new alkaloids with the absolute configurations were elucidated by means of spectroscopic methods, electronic circular dichroism (ECD) and calculated nuclear magnetic resonance (NMR) with DP4+ analysis. Compounds 1 and 2 exhibited certain activity to Con-A induced T cell proliferation, and 1 exhibited good inhibition on LPS-induced B cell proliferation with an IC50 value of 8.7 μM.
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