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MicroRNAs and Mammarenaviruses: Modulating Cellular Metabolism
Jorlan Fernandes1, Renan Lyra Miranda2, Elba Regina Sampaio de Lemos1
1Hantaviruses and Rickettsiosis Laboratory, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.
Cells
|November 26, 2020
Summary
Mammarenavirus infection reprograms host cell metabolism by manipulating microRNAs (miRNAs). This impacts amino acid and thiamine metabolism, offering potential therapeutic targets for hemorrhagic fevers.
Area of Science:
- Virology
- Molecular Biology
- Metabolic Engineering
Background:
- Mammarenaviruses are emerging viruses causing severe hemorrhagic fevers.
- Viral infections profoundly impact host cell microRNA (miRNA) expression.
- Understanding virus-host interactions is key for therapeutic development.
Purpose of the Study:
- Investigate how mammarenavirus infection affects host cell metabolism.
- Explore the role of cellular microRNAs in mammarenavirus-induced metabolic changes.
- Identify potential diagnostic and therapeutic targets.
Main Methods:
- Analysis of miRNA expression profiles post-mammarenavirus infection.
- Bioinformatic prediction of miRNA targets in metabolic pathways.
- Assessment of metabolic pathway alterations, including amino acid and thiamine metabolism.
Main Results:
- Mammarenavirus infection induces significant metabolic reprogramming in host cells.
- Predicted miRNAs, no longer regulating specific pathways, were identified.
- Impacts observed in valine, leucine, isoleucine biosynthesis, and d-glutamine/d-glutamate metabolism.
Conclusions:
- Mammarenavirus infection likely manipulates cellular miRNAs to reprogram host metabolism.
- Altered metabolic pathways present potential targets for antiviral therapies.
- Further research into these mechanisms is critical for understanding virus-host interactions.
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