Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In-situ Hybridization02:31

In-situ Hybridization

10.1K
In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
10.1K
Introduction to Plant Diversity02:22

Introduction to Plant Diversity

47.7K
From Water to Land
47.7K
Diversity of Protists III01:27

Diversity of Protists III

560
Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
560
Diversity of Protists IV01:27

Diversity of Protists IV

582
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
582
Diversity of Protists I01:15

Diversity of Protists I

653
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
653
Diversity of Protists II01:27

Diversity of Protists II

625
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential of Dietary Agent Daidzein in Cancer Prevention and Treatment: Opportunities and Challenges.

Cancers·2026
Same author

Targeting signaling cascades by bioactive phytocompounds in osteosarcoma: A novel therapeutic approach.

Pharmacology & therapeutics·2026
Same author

Mechanistic insights into the anticancer potential of ruthenium(II) paracymene complexes of phenolic acids.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Unmasking NLRX1: Exploring the broadening biological landscape of a mysterious mitochondrial sensor.

Mitochondrion·2026
Same author

<b>A</b> nickel incorporated triazine-based porous organic polymer for the electrocatalytic methanol oxidation reaction.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Miracle berry for management of cancer and cancer treatment-related adverse effects.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025

Related Experiment Video

Updated: Nov 28, 2025

The Use of Induced Somatic Sector Analysis ISSA for Studying Genes and Promoters Involved in Wood Formation and Secondary Stem Development
09:54

The Use of Induced Somatic Sector Analysis ISSA for Studying Genes and Promoters Involved in Wood Formation and Secondary Stem Development

Published on: October 5, 2016

9.0K

Isatin: A Scaffold with Immense Biodiversity.

Priyobrata Nath1, Agnish Mukherjee1, Sougata Mukherjee1

  • 1Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301 West Bengal, India.

Mini Reviews in Medicinal Chemistry
|November 26, 2020
PubMed
Summary

Isatin, a fused heterocyclic compound, exhibits diverse biological activities including antimicrobial and anticancer effects. Its derivatives are crucial in synthesizing potential drug candidates, with specific chemical modifications enhancing therapeutic efficacy.

Keywords:
Isatinanti-canceranti-inflammatory.anti-microbialanti-tubercularanticonvulsant

More Related Videos

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

31.6K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.0K

Related Experiment Videos

Last Updated: Nov 28, 2025

The Use of Induced Somatic Sector Analysis ISSA for Studying Genes and Promoters Involved in Wood Formation and Secondary Stem Development
09:54

The Use of Induced Somatic Sector Analysis ISSA for Studying Genes and Promoters Involved in Wood Formation and Secondary Stem Development

Published on: October 5, 2016

9.0K
The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

31.6K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.0K

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Isatin is an endogenous fused heterocyclic compound with a significant indole nucleus.
  • It possesses both lactam and keto moieties, contributing to its diverse biological activities.

Purpose of the Study:

  • To review the chemistry of isatin and its derivatives.
  • To highlight their significance in altering pathological states.
  • To provide extensive information on synthesis and applications.

Main Methods:

  • Literature review of synthesis, chemical properties, and biological applications of isatin.
  • Structure-Activity Relationship (SAR) analysis of isatin derivatives.
  • Survey of existing scientific information on isatin's role in pathology.

Main Results:

  • Isatin derivatives exhibit a broad spectrum of biological effects, including antimicrobial, anti-tubercular, anticonvulsant, and anticancer activities.
  • Structure-activity relationship studies indicate that electron-withdrawing groups (halogens, nitro, alkoxy) and some electron-donating groups (methyl) at specific positions enhance therapeutic effects.
  • Fusion with other heterocycles at positions 2 and 3 can lead to biologically relevant compounds, sometimes making the oxo groups less critical.

Conclusions:

  • Isatin and its derivatives are versatile scaffolds for developing novel therapeutic agents.
  • Strategic chemical modifications, guided by SAR, are key to optimizing biological activity for various clinical conditions.
  • Further exploration of isatin derivatives holds promise for drug discovery and development.