Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomaterial-Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Closed-loop iron chelate recycling via molecularly imprinted hydrogels suppresses ferroptosis.

Nature communications·2026
Same author

Dual-function hydrogel microspheres coordinate immune regulation and osteogenesis coupling to promote femoral regeneration.

Journal of materials chemistry. B·2026
Same author

Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia.

Science translational medicine·2026
Same author

In Situ Stress-Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration.

Nature communications·2026
Same journal

Taphonomic analysis at Liang Bua reveals the behavioral and technological capabilities of <i>Homo floresiensis</i>.

Science advances·2026
Same journal

Targeting granule initiation and amyloplast structure to create giant starch granules in wheat.

Science advances·2026
Same journal

A meta-analysis of carbon losses and gains from tropical moist forest degradation and regeneration.

Science advances·2026
Same journal

Ancient DNA reveals elite dynastic rule among Iron Age Eurasian Steppe nomads.

Science advances·2026
Same journal

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m<sup>6</sup>A regulation of MMP2.

Science advances·2026
Same journal

Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets.

Science advances·2026
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

12.8K

ECM-inspired micro/nanofibers for modulating cell function and tissue generation.

Yun Xu1,2, Guodong Shi2, Jincheng Tang1

  • 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215006, P.R. China.

Science Advances
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel biomimetic scaffold that mimics the dura mater's extracellular matrix. The heterogeneous scaffold promotes dura regeneration while preventing scar tissue formation, offering a promising solution for dura repair.

More Related Videos

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
07:50

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

5.6K
Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

13.7K

Related Experiment Videos

Last Updated: Nov 28, 2025

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

12.8K
Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
07:50

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

5.6K
Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
11:19

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

13.7K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Current homogeneous biomimetic scaffolds fail to replicate the complex regenerative microenvironment of the native extracellular matrix.
  • Dura mater regeneration presents challenges due to its unique structural and functional properties.

Purpose of the Study:

  • To develop an extracellular matrix-mimicking scaffold with biomimetic heterogeneous features for dura mater repair.
  • To investigate the scaffold's ability to orchestrate fibroblast behavior and suppress myofibroblast activity.
  • To elucidate the underlying molecular mechanisms, including integrin signaling pathways.

Main Methods:

  • Fabrication of a heterogeneous fibrous scaffold with distinct inner and outer surface properties.
  • Characterization of the scaffold's anisotropic topology and chemical cues.
  • In vitro assessment of fibroblast and myofibroblast responses.
  • In vivo evaluation in a rabbit laminectomy model for dura regeneration and fibrosis inhibition.
  • Verification of integrin β1 and Yes-associated protein (YAP) signaling pathways.

Main Results:

  • The scaffold's inner surface promoted fibroblast elongation and bipolarization while maintaining a quiescent phenotype (down-regulated α-smooth muscle actin).
  • The outer surface effectively suppressed myofibroblast fibrotic activity through increased microfiber density.
  • Topological and chemical cues activated integrin β1 and YAP signaling pathways.
  • In vivo studies demonstrated simultaneous promotion of dura regeneration and inhibition of epidural fibrosis.

Conclusions:

  • The developed heterogeneous fibrous scaffold successfully mimics the microstructure and function of natural dura mater.
  • This biomimetic approach offers a promising strategy for effective dura mater regeneration and prevention of fibrosis.
  • The findings provide insights into the molecular mechanisms governing tissue regeneration and fibrosis through scaffold-matrix interactions.