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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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An Integrated Approach for Microprotein Identification and Sequence Analysis
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Accessing NCBI data using the NCBI Sequence Viewer and Genome Data Viewer (GDV).

Sanjida H Rangwala1, Anatoliy Kuznetsov1, Victor Ananiev1

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.

Genome Research
|November 26, 2020
PubMed
Summary
This summary is machine-generated.

The National Center for Biotechnology Information (NCBI) offers free access to biological data and tools. Researchers can use the Genome Data Viewer (GDV) and Sequence Viewer (SV) to analyze and display genetic sequences.

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Area of Science:

  • Biotechnology
  • Bioinformatics
  • Genomics

Background:

  • The National Center for Biotechnology Information (NCBI) archives vast biological sequence data and literature.
  • NCBI staff provide gene and SNP annotation and develop sequence alignment tools.
  • The Genome Data Viewer (GDV) displays RefSeq annotation and integrates with other NCBI resources.

Purpose of the Study:

  • To describe how researchers can utilize NCBI's Genome Data Viewer (GDV) and Sequence Viewer (SV).
  • To demonstrate accessing, analyzing, and disseminating biomedical sequence data.
  • To explain embedding the NCBI Sequence Viewer (SV) into external web pages for custom visualization.

Main Methods:

  • Utilizing the Genome Data Viewer (GDV) for data exploration and analysis.
  • Leveraging the NCBI Sequence Viewer (SV) for detailed sequence visualization.
  • Implementing SV into custom web applications for data dissemination.

Main Results:

  • GDV provides integrated access to diverse NCBI resources and custom analysis platforms.
  • SV enables detailed graphical display of biomedical sequence data.
  • Users can embed SV into their websites for customized data visualization without significant infrastructure investment.

Conclusions:

  • GDV and SV are powerful tools for the biomedical research community to manage and visualize sequence data.
  • Embedding SV offers a flexible solution for custom data presentation.
  • NCBI resources facilitate efficient access, analysis, and dissemination of biological information.