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Updated: Nov 28, 2025

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
Optical coherence tomography (OCT) in neuro-ophthalmology
Neda Minakaran1, Emanuel R de Carvalho2,3, Axel Petzold2,4,5
1Moorfields Eye Hospital NHS Foundation Trust, London, UK. neda.minakaran@gmail.com.
Abstract:
Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and OCT-based imaging techniques in the neuro-ophthalmic context, potential pitfalls to be aware of, and specific applications in more common neuro-ophthalmic conditions including demyelinating, inflammatory, ischaemic and compressive optic neuropathies, optic disc drusen and raised intracranial pressure. We also review emerging applications of OCT angiography within neuro-ophthalmology.
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