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Natural Fish Trap-Like Nanocage for Label-Free Capture of Circulating Tumor Cells
Wenning Jiang1, Lulu Han1, Liwei Yang1
1Liaoning Key Laboratory of Molecular Recognition and Imaging School of Bioengineering Dalian University of Technology Dalian 116023 P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 26, 2020
Summary
Researchers developed a novel nanocage film from Chrysanthemum pollen for efficient, label-free capture of circulating tumor cells (CTCs). This natural nanomaterial effectively isolates rare cancer cells and clusters from patient blood samples.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Research
Background:
- Nanomaterials show promise for capturing circulating tumor cells (CTCs).
- Developing label-free nanomaterials for high-efficiency CTC capture remains a challenge.
- Nature offers complex hierarchical structures through evolution.
Purpose of the Study:
- To construct a novel nanocage-featured film for label-free capture of CTCs and CTC clusters.
- To investigate the efficiency and broad applicability of the nanocage film for cancer cell isolation.
Main Methods:
- Fabrication of a nanocage-featured film using Chrysanthemum pollen.
- Evaluation of the film's capture efficiency for rare cancer cells and CTC clusters.
- Testing the film with blood samples from cancer patients.
Main Results:
- The nanocage film achieved 92% capture efficiency for rare cancer cells across various types.
- Effective capture was attributed to nanocage-CTC filopodia matching, high contact area, and adhesion.
- The film successfully detected CTCs and CTC clusters in blood from 21 cancer patients (stages I-IV).
Conclusions:
- A novel, fish trap-like nanocage structure derived from natural Chrysanthemum pollen was developed.
- The nanocage-featured film enables efficient, label-free capture of CTCs and CTC clusters.
- This natural nanomaterial offers a promising, economical approach for clinical CTC capture and analysis.
