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The circadian clock and inflammation: A new insight
Hui Xu1, Lingli Huang2, Jiajia Zhao1
1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 26, 2020
Summary
The circadian clock regulates inflammation by interacting with key inflammatory pathways. This review explores these interactions and how inflammation disrupts biological rhythms, worsening tissue damage.
Area of Science:
- * Chronobiology and immunology
- * Molecular mechanisms of circadian rhythm and inflammation
Background:
- * The circadian clock is a fundamental cellular mechanism governing physiological processes.
- * Inflammation is a critical biological response with known links to circadian rhythm disruption.
Purpose of the Study:
- * To review the core proteins of the circadian clock.
- * To elucidate the physical interactions between circadian clock components and inflammatory pathway players.
- * To propose mechanisms for pathological rhythms in inflammatory conditions.
Main Methods:
- * Literature review of existing research on circadian clock proteins and inflammation.
- * Analysis of molecular interactions between circadian and inflammatory pathways.
- * Synthesis of data to explain rhythm disturbances under inflammation.
Main Results:
- * Circadian clock proteins physically interact with key inflammatory pathway components.
- * Inflammation can disrupt normal circadian rhythms.
- * Disrupted rhythms can exacerbate inflammation and tissue damage.
Conclusions:
- * There is a bidirectional relationship between the circadian clock and inflammation.
- * Understanding these interactions may reveal therapeutic targets for inflammatory diseases.
- * Pathological rhythms observed in inflammation are linked to molecular crosstalk.
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