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Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study
Chun Feng1, Ping-Ping Lv2, Chang-Chang Huang1
1Department of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Background And Aims:
It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females.
Methods:
A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a 13/14C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method.
Results:
Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP- groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP- groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05).
Conclusions:
There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.
Insights
Helicobacter pylori (HP) infection did not impact male sperm quality or female ovarian reserve in this study of Chinese patients. Further research is needed to fully understand the relationship between HP infection and fertility outcomes.
Area of Science:
- Reproductive Medicine
- Gastroenterology
- Infectious Diseases
Background:
- Helicobacter pylori (HP) infection is increasingly recognized in infertile populations.
- Previous studies suggest HP infection may negatively affect sperm parameters and that treatment could improve sperm quality.
- Limited evidence necessitates further investigation into the HP infection-infertility link.
Purpose of the Study:
- To investigate the impact of HP infection on sperm quality in males.
- To assess the effect of HP infection on ovarian reserve in females.
- To provide evidence for the relationship between HP infection and fertility.
Main Methods:
- Retrospective cross-sectional study of 16,522 patients undergoing HP testing.
- Analysis of sperm parameters (concentration, motility) in 363 patients.
- Assessment of serum anti-Müllerian hormone (AMH) levels in 202 patients.
Main Results:
- No significant differences in sperm concentration or motility were observed between HP-positive and HP-negative groups.
- Subgroup analyses and pooled data analysis confirmed no impact of HP infection on sperm parameters.
- Serum AMH levels were similar between HP-positive and HP-negative groups, with no significant differences in subgroup analyses.
Conclusions:
- HP infection history showed no association with altered sperm parameters in males.
- HP infection history did not correlate with ovarian reserve as measured by AMH levels in females.
- Findings suggest no direct impact of HP infection on male or female fertility markers in the studied Chinese population.
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