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Tiotropium in the management of paediatric and adolescent asthma: Systematic review
Meera Sunther1, Keisha Marchon1, Atul Gupta2
1Department of Respiratory Paediatrics, King's College Hospital, London, UK.
Abstract:
Tiotropium bromide is a long-acting muscarinic antagonist (LAMA) and is the only LAMA licensed for management for patients' ≥6 years old with severe asthma who have experienced one or more severe asthma exacerbations in the preceding year. Recent clinical trials have demonstrated that once-daily tiotropium is safe and efficacious in 6-17 year-olds with symptomatic asthma despite treatment with inhaled corticosteroids (ICSs), with or without additional controllers. In this paper, we review the evidence of the safety and efficacy of tiotropium add-on maintenance treatment in children and adolescents with symptomatic moderate and severe asthma.
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