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Related Experiment Video

Updated: Nov 28, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Advances in transcriptome analysis of human brain aging.

Seokjin Ham¹, Seung-Jae V Lee²

¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea. sjham@kaist.ac.kr.

Experimental & Molecular Medicine

|November 27, 2020

Summary

Brain aging involves changes in gene expression, affecting cognitive function. Transcriptome analysis reveals decreased synaptic and increased immune activity, offering insights into cognitive decline and neurodegenerative diseases.

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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Area of Science:

Neuroscience
Genomics
Aging Research

Background:

Aging leads to physiological decline, including cognitive impairment.
Whole-transcriptome changes in the brain are linked to age-associated cognitive decline.

Purpose of the Study:

To review transcriptome-based research on human brain aging.
To understand gene expression alterations underlying cognitive aging.

Main Methods:

Analysis of microarray and RNA sequencing data from human brain samples of varying ages.
Examination of transcriptome-wide changes associated with aging.

Main Results:

Aged brains show decreased synaptic function and increased immune function across most regions.
Gene expression changes are cell-type, region, and genotype-dependent.
Transcriptome alterations include splicing variations, heterogeneity, and noncoding RNA level changes.

Conclusions:

Transcriptome-based hallmarks are crucial for understanding brain aging and cognitive decline.
Insights into brain aging can inform strategies for neurodegenerative diseases.
Identifying transcriptome changes may lead to interventions to delay or prevent brain aging.