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Updated: Nov 28, 2025

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Focus on gastroesophageal reflux disease in patients with cystic fibrosis

Annarita Bongiovanni1, Sara Manti2, Giuseppe Fabio Parisi1

  • 1Department of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania, Catania 95123, Italy.

World Journal of Gastroenterology
|November 27, 2020
PubMed

Insights

Gastroesophageal reflux disease (GERD) is common in cystic fibrosis (CF) patients, often starting in childhood. This review covers GERD

Area of Science:

  • Gastroenterology and Pulmonology
  • Pediatric Health

Background:

  • Gastroesophageal reflux disease (GERD) is a frequent comorbidity in cystic fibrosis (CF).
  • GERD prevalence in CF patients is notably high, often manifesting in childhood.
  • Existing diagnostic and therapeutic guidelines for GERD are not specific to CF patients.

Purpose of the Study:

  • To review the pathophysiology linking CF and GERD.
  • To outline diagnostic and therapeutic strategies for GERD in CF.
  • To discuss complications and future management directions for GERD in CF.

Main Methods:

  • Literature review of studies on GERD in CF patients.
  • Analysis of pathogenetic mechanisms connecting CF and GERD.
  • Synthesis of current diagnostic and treatment approaches.

Main Results:

  • Multiple pathogenetic mechanisms contribute to the CF-GERD association.
  • Current GERD management in CF relies on non-CF-specific guidelines.
  • There is a need for tailored approaches to GERD in CF.

Conclusions:

  • Understanding the unique aspects of GERD in CF is crucial.
  • Development of CF-specific GERD guidelines is warranted.
  • Further research is needed to optimize GERD management in cystic fibrosis.

Keywords:
AdultChildrenCystic FibrosisGastroesophageal reflux

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