Related Experiment Video For Lung cancer
Updated: Nov 28, 2025
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
Lung cancer screening in Appalachian Kentucky: The impact of Lung-RADS on subsequent testing and cancer
Roberto Cardarelli1, Vashisht Madabhushi2, Kacie Bledsoe3
1Department of Family & Community Medicine, University of Kentucky, College of Medicine, 2195 Harrodsburg Road, Lexington, KY, 40504-3504 USA.
Abstract:
The National Lung Cancer Screening Trial (NLST) demonstrated the use of low dose helical computed tomography (LDCT) scans for lung cancer screening. However, the NLST was implemented in urban hospitals and prior to the Lung CT Screening Reporting and Data System (Lung-RADS). In this retrospective cohort study, 774 eligible patients received LDCT screening using Lung-RADS criteria. Eighty-four patients (10.9%) had subsequent testing performed compared to 24.2% in the NLST study. Of those with subsequent testing, 21.4% were diagnosed with lung cancer compared to only 4.6% in the NLST study. Lung-RADS significantly reduced unnecessary testing while identifying higher rates of lung cancer compared to the NLST.
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