Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

908
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
908
CRISPR01:59

CRISPR

55.5K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
55.5K
Cancer Vaccines01:30

Cancer Vaccines

690
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
690
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

1.1K
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
1.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic and Meat Quality Differences in Longissimus Dorsi Muscle of Surgically Castrated Three-Year-Old Kazakh Horses.

Biology·2026
Same author

CRISPR Screening in Hepatocellular Carcinoma: From Tumor Progression to Immune Evasion and Therapeutic Resistance.

International journal of molecular sciences·2026
Same author

Pea protein isolate as a versatile and sustainable protein: basic characteristics, applications, and limitations.

Food chemistry·2026
Same author

Curdlan, a functionally microbial extracellular polysaccharide with versatile food applications.

Food chemistry·2026
Same author

Genome-Wide CRISPR Screening Identifies Genetic Modulators of Amyloid Precursor Protein Processing.

International journal of molecular sciences·2026
Same author

Stabilization and color protection of phycoerythrin hydrolysate through agarose oligosaccharide complexation.

Journal of the science of food and agriculture·2026
Same journal

Cyclic Stiffness Modulation of Cell-Laden Protein-Polymer Hydrogels in Response to User-Specified Stimuli including Light.

Advanced biosystems·2021
Same journal

Biomimetic microgels with controllable deformability improve healing outcomes.

Advanced biosystems·2021
Same journal

Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification.

Advanced biosystems·2020
Same journal

The Magical World of Circulating Vesicles.

Advanced biosystems·2020
Same journal

On the Assembly of Microreactors with Parallel Enzymatic Pathways.

Advanced biosystems·2020
Same journal

A Dual Role of Type I Interferons in Antitumor Immunity.

Advanced biosystems·2020
See all related articles

Related Experiment Video

Updated: Nov 28, 2025

Production of Human CRISPR-Engineered CAR-T Cells
06:33

Production of Human CRISPR-Engineered CAR-T Cells

Published on: March 15, 2021

13.8K

Improving Cancer Immunotherapy with CRISPR-Based Technology.

Zexu Li1,2, Teng Fei1,2

  • 1College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.

Advanced Biosystems
|November 27, 2020
PubMed
Summary
This summary is machine-generated.

CRISPR technology is revolutionizing cancer immunotherapy by enabling genetically engineered immune cells and enhancing our understanding of anti-tumor responses. This review explores CRISPR

Keywords:
cancer immunotherapychimeric antigen receptor-Tclustered regularly interspaced palindromic repeatsgenome editingimmune checkpoints

More Related Videos

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells
07:56

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells

Published on: July 22, 2019

11.6K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

835

Related Experiment Videos

Last Updated: Nov 28, 2025

Production of Human CRISPR-Engineered CAR-T Cells
06:33

Production of Human CRISPR-Engineered CAR-T Cells

Published on: March 15, 2021

13.8K
Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells
07:56

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells

Published on: July 22, 2019

11.6K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

835

Area of Science:

  • Cancer Immunology and Immunotherapy
  • Biomedical Research
  • Genome Editing Technology

Background:

  • Immunotherapy has transformed cancer treatment standards.
  • Genetically engineered T cells (CAR-T and TCR-T) are potent anti-cancer weapons.
  • Immune checkpoint blockade (targeting CTLA-4 and PD-1) is a key immunotherapy strategy.

Purpose of the Study:

  • To review the impact of CRISPR technology on cancer immunology research.
  • To discuss the application of CRISPR in developing novel cancer immunotherapies.
  • To predict the future of cancer immunotherapy with CRISPR advancements.

Main Methods:

  • Review of current literature on CRISPR applications in cancer immunology.
  • Analysis of CRISPR's role in engineering immune cells (T cells, NK cells, macrophages).
  • Discussion of CRISPR's contribution to understanding immune checkpoints and anti-tumor immunity.

Main Results:

  • CRISPR-based tools significantly accelerate biomedical research, including cancer immunology.
  • CRISPR facilitates the development of advanced cell-based immunotherapies.
  • CRISPR enhances the study of immune cell functions against cancer.

Conclusions:

  • CRISPR technology is a pivotal tool in advancing cancer immunology and immunotherapy.
  • The integration of CRISPR promises innovative therapeutic strategies for cancer treatment.
  • Future cancer immunotherapy will likely leverage CRISPR for enhanced efficacy and precision.