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Q fever vaccines: present status and application in man
Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
|November 1, 1987
Summary
Two Q fever vaccine candidates show promise for vaccinating at-risk individuals, demonstrating good immunogenicity and low reactogenicity. Further research is needed to determine the optimal vaccine type and address Coxiella burnetii strain diversity.
Area of Science:
- Vaccinology
- Infectious Diseases
- Microbiology
Background:
- Q fever is a zoonotic disease caused by Coxiella burnetii.
- Vaccine development is crucial for preventing Q fever outbreaks.
- Three vaccine candidates have been developed: untreated corpuscular, soluble, and chloroform-methanol treated corpuscular vaccines.
Purpose of the Study:
- To evaluate the immunogenicity and reactogenicity of Q fever vaccine candidates.
- To determine the suitability of existing vaccine candidates for human use.
- To identify future research directions for Q fever vaccine development.
Main Methods:
- Clinical trials involving hundreds of subjects exposed to Q fever.
- Assessment of vaccine immunogenicity through various tests.
- Monitoring of vaccine reactogenicity in vaccinated subjects.
Main Results:
- The untreated corpuscular and soluble vaccine candidates demonstrated sufficient immunogenicity.
- Both recommended vaccines exhibited low reactogenicity when individuals with prior Coxiella burnetii exposure were excluded.
- The study identified the need for further investigation into vaccine efficacy and strain variability.
Conclusions:
- The untreated corpuscular and soluble Q fever vaccines are recommended for at-risk populations.
- Excluding individuals with prior C. burnetii exposure is crucial for minimizing vaccine reactogenicity.
- Further studies are required to determine the optimal vaccine strategy, considering C. burnetii strain heterogeneity and the potential need for polyvalent vaccines.