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Early Postoperative Magnetic Resonance in the Diagnosis of Persistent Juvenile Angiofibroma
Alberto Schreiber1, Marco Ravanelli2, Marco Ferrari1,3
1Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Objectives/Hypothesis:
Despite improvements in the treatment of juvenile angiofibroma (JA), the rate of persistence (pJA) is still not negligible. In the present study, we assessed the value of early postoperative magnetic resonance imaging (MRI) in depicting unintentional pJAs and designed a MRI-driven decisional flow-chart for pJA management and follow-up.
Study Design:
Observational study.
Methods:
Patients undergoing early postoperative MRI after endoscopic resection of JA in the Unit of Otorhinolaryngology - ASST Spedali Civili, University of Brescia from 2007 to 2017 were enrolled. MRI was defined as negative or positive based on defined radiological criteria. The diagnostic performance of MRI was evaluated.
Results:
The analysis included 26 patients, with a mean age of 16.5 years (range, 11-25). Early MRI was negative for pJA in 21 (80.8%) patients and positive in five (19.2%). No patient with a negative finding was found positive at subsequent follow-up MRIs. The accuracy of a positive finding was confirmed by pathologic examination (three cases) or follow-up MRIs (two cases). The diagnostic performance of MRI was excellent with sensitivity and specificity of 100%. An MRI-driven flow-chart for pJA management and follow-up was designed.
Conclusions:
Early postoperative MRI demonstrated a high diagnostic accuracy in the detection of unintentional pJA. Our MRI-driven strategy and decisional flow-chart could aid in the decision-making process in the management of pJA and definition of postoperative surveillance.
Level Of Evidence:
4 Laryngoscope, 131:E2436-E2441, 2021.
Insights
Early postoperative MRI accurately detects persistent juvenile angiofibroma (pJA) after endoscopic resection. This imaging-guided strategy improves pJA management and follow-up surveillance.
Area of Science:
- Otorhinolaryngology
- Radiology
- Oncology
Background:
- Juvenile angiofibroma (JA) treatment can result in persistent disease (pJA).
- Effective methods for detecting pJA post-surgery are crucial for optimal patient management.
- Current follow-up strategies may not always be sufficient to identify residual JA.
Purpose of the Study:
- To evaluate the diagnostic accuracy of early postoperative MRI in detecting unintentional pJA.
- To develop an MRI-driven flowchart for managing and monitoring patients with pJA.
- To enhance the decision-making process for pJA surveillance.
Main Methods:
- Observational study including 26 patients who underwent endoscopic JA resection.
- Early postoperative MRI was performed and analyzed for residual pJA based on radiological criteria.
- Diagnostic performance of MRI was assessed, and an MRI-driven management flowchart was designed.
Main Results:
- Early postoperative MRI detected pJA in 19.2% of patients (5 out of 26).
- MRI demonstrated excellent diagnostic performance with 100% sensitivity and specificity.
- No patients with negative MRI findings showed pJA on subsequent follow-up.
Conclusions:
- Early postoperative MRI is highly accurate for detecting unintentional pJA.
- An MRI-driven strategy and flowchart can guide pJA management and surveillance.
- This approach aids in defining appropriate postoperative follow-up protocols.
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