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Reference values of retinal microcirculation parameters derived from a population random sample.

Renata Cífková1, Joanna M Harazny2, Jan Bruthans3

  • 1Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic; Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.

Microvascular Research
|November 27, 2020
PubMed
Summary
This summary is machine-generated.

This study establishes reference values for retinal microcirculation parameters in a Caucasian population, revealing age-related changes and links between blood pressure, aortic stiffness, and retinal vascular remodeling.

Keywords:
Czech post-MONICA studyJuxtapapillary retinal capillary blood flowLuminal diameterRetinal vascular resistanceScanning laser Doppler flowmetryVessel diameterWall cross-sectional areaWall thicknessWall-to-lumen ratio

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Area of Science:

  • Ophthalmology
  • Cardiovascular Medicine
  • Physiology

Background:

  • Retinal microcirculation changes can indicate early cardiovascular disease.
  • Establishing population-specific reference values is crucial for early detection.

Purpose of the Study:

  • To determine reference values for retinal microcirculation parameters in a randomly selected urban Caucasian population.
  • To investigate age and sex differences in these parameters.
  • To explore relationships between retinal microcirculation, blood pressure, and aortic stiffness.

Main Methods:

  • Scanning laser Doppler flowmetry (SLDF) was used to assess retinal microcirculation in 343 individuals.
  • A reference population of 256 individuals free from major cardiovascular risk factors was selected.
  • Statistical analyses adjusted for age, blood pressure, and aortic stiffness (carotid-femoral pulse wave velocity).

Main Results:

  • Retinal capillary blood flow increased with age, while vessel and lumen diameters decreased.
  • No significant sex differences were observed in retinal microcirculation parameters.
  • Blood pressure correlated with retinal arteriolar wall thickness and wall-to-lumen ratio; aortic stiffness correlated with retinal arteriole remodeling.

Conclusions:

  • This study provides the first population-based reference values for retinal microcirculation parameters in Caucasians.
  • Age-related changes in lumen diameter are the earliest structural alterations in retinal microcirculation.
  • Interactions exist between systemic blood pressure, aortic stiffness, and retinal microvascular structure.