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Pyrophosphates in toothpaste: a retrospective and reappraisal
1Department of Oral Surgery, University of Leeds School of Dentistry, Worsley Building, Clarendon Way, Leeds, LS2 9LU, UK. r.s.levine@leeds.ac.uk.
British Dental Journal
|November 28, 2020
Summary
Pyrophosphate toothpastes prevent tartar but may reduce fluoride
Area of Science:
- Dental Science
- Biochemistry
Background:
- Pyrophosphates are widely used in toothpastes as anti-tartar agents, inhibiting calcium phosphate deposition.
- These chelating agents are known to inhibit hydroxyapatite crystal growth, potentially affecting tooth demineralization-remineralization balance.
Purpose of the Study:
- To investigate whether pyrophosphates in toothpaste compromise the anti-cavity efficacy of fluoride.
Main Methods:
- Review of existing clinical research on pyrophosphate-containing toothpastes and their effect on caries protection.
- Analysis of theoretical implications of pyrophosphates on the tooth surface's mineral equilibrium.
Main Results:
- Limited and inconsistent clinical evidence exists regarding the impact of pyrophosphates on fluoride's caries protection.
- Theoretical concerns suggest pyrophosphates might interfere with the natural remineralization process of teeth.
Conclusions:
- More clinical research is needed to definitively assess the interaction between pyrophosphates and fluoride in preventing cavities.
- Due to insufficient evidence, pyrophosphate-containing toothpastes are not recommended for children under 12 years old.
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