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Updated: Nov 28, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Mass spectrometrical and quantum-chemical study of pentafluorophenylhydrazones
Dušan Bortňák1, Daniel Pecher2, Daniel Végh1
1Department of Organic Chemistry, Slovak Technical University, Radlinského 9, Bratislava, SK-812 37, Slovakia.
Abstract:
Twenty-one pentafluorphenylhydrazones have been analyzed by means of tandem mass spectrometry (ESI MS/MS) conditions to compare their fragmentations with those ones obtained from quantum-chemical calculations of the hydrazone moiety depending on the substitution from the aldehyde site. The hydrazone N-N bond is disrupted under such conditions, and these results are in accordance with the facts that an electron-rich particle, such as an anion and or radical in a solution, can cause this disruption and simultaneous defluorination in para-position of the hydrazone part of the molecule.
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