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Childhood Cancer Survival in Brunei Darussalam

Elvynna Leong1,2, Sok King Ong3, Fadzilah Jali1

  • 1Faculty of Science, Universiti Brunei Darussalam, Jln Tungku Link, Brunei Darussalam.

Asian Pacific Journal of Cancer Prevention : APJCP
|November 28, 2020
PubMed

Insights

Childhood cancer survival rates in Brunei Darussalam are 79.4% at 1 year and 70.0% at 5 years. Survival is influenced by cancer type, age at diagnosis, and treatment period, aiding cancer control program planning.

Area of Science:

  • Pediatric Oncology
  • Cancer Epidemiology
  • Public Health

Background:

  • Childhood cancer survival rates in Brunei Darussalam are not well-established.
  • Understanding survival factors is crucial for improving outcomes in pediatric cancer patients.

Purpose of the Study:

  • To determine overall survival rates for children and adolescents (0-19 years) diagnosed with cancer in Brunei Darussalam.
  • To identify factors associated with childhood cancer survival.

Main Methods:

  • Analysis of 263 de-identified childhood cancer cases from 2002-2017 using a population-based cancer registry.
  • Kaplan-Meier method for overall survival estimation.
  • Log-rank and Cox Proportional Hazard (PH) regression analyses to identify significant survival factors.

Main Results:

  • Overall 1-, 5-, and 10-year survival rates were 79.4%, 70.0%, and 68.8%, respectively.
  • Malignant epithelial neoplasms had the highest 5-year survival (84.2%), while CNS tumors had the lowest (44.1%).
  • Lymphomas, gonadal/germ cell neoplasms, malignant epithelial neoplasms, younger age groups, and earlier diagnosis periods were associated with lower mortality hazard.

Conclusions:

  • Establishes baseline childhood cancer survival data for Brunei Darussalam.
  • Provides evidence for targeted cancer control strategies, including surveillance, screening, and treatment.
  • Aims to improve childhood cancer survival rates through informed program planning.
Abstract

Keywords:
Cox PHPrognostic factorcancer registryhazardpopulation-based

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