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Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci
L M McMurry1, B H Park, V Burdett
1Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Antimicrobial Agents and Chemotherapy
|October 1, 1987
Abstract:
The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.