The relationship between a novel evaluation parameter of premature luteinization and IVF outcomes

Area of Science:

• Reproductive Medicine
• In Vitro Fertilization (IVF)
• Endocrinology

Background:

• Premature luteinization of granulosa cells (PLGC) is a phenomenon in IVF.
• Its impact on IVF outcomes and potential as a diagnostic parameter require further investigation.

Purpose of the Study:

• To investigate whether premature luteinization of granulosa cells (PLGC) can serve as a novel parameter for premature luteinization.
• To assess the effect of PLGC on in vitro fertilization (IVF) outcomes.

Main Methods:

• Retrospective cohort study of 42,468 fresh IVF cycles.
• Propensity score matching was used to create PLGC and control groups.
• Key outcomes included pregnancy and live birth rates.

Main Results:

• The PLGC group showed significantly worse oocyte and embryo development post-matching.
• Lower rates of metaphase II oocytes, two-pronuclei, available embryos, blastocyst formation, and high-quality blastocysts were observed in the PLGC group.
• Pregnancy, implantation, and live birth rates were also reduced in the PLGC group. Elevated progesterone levels (>1.5 ng/ml) correlated with PLGC.

Conclusions:

• Premature luteinization of granulosa cells (PLGC) adversely affects oocyte competency and IVF success rates.
• PLGC can be a valuable novel parameter for judging premature luteinization.
• Close progesterone monitoring and analysis are crucial for individualized treatment and reducing PLGC incidence.