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Related Experiment Video

Updated: Nov 28, 2025

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

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Sleeve Gastrectomy in Mice using Surgical Clips.

Jih-Hua Wei1, Che-Hung Yeh2, Wei-Jei Lee3

  • 1Cardiovascular Division, Internal Medicine Department, Min-Sheng General Hospital; Department of Nutrition and Health Sciences, School of Healthcare Management, Kai-Nan University; Institute of Clinical Medicine, National Yang-Ming University.

Journal of Visualized Experiments : Jove
|November 30, 2020
PubMed
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Obesity and type 2 diabetes are rising globally. This study presents a simple animal model for studying bariatric surgery (sleeve gastrectomy) to understand its metabolic benefits and mechanisms.

Area of Science:

  • Metabolic surgery
  • Preclinical research
  • Obesity and diabetes research

Background:

  • Rising global rates of obesity and type 2 diabetes (T2D) necessitate effective treatments.
  • Bariatric surgery, specifically sleeve gastrectomy (SG), is a leading treatment for obesity and T2D.
  • The precise mechanisms linking bariatric surgery to metabolic improvements require further investigation.

Purpose of the Study:

  • To establish a straightforward and uncomplicated preclinical animal model for bariatric surgery.
  • To facilitate research into the mechanisms underlying the metabolic benefits of bariatric procedures.
  • To provide a valuable tool for researchers studying obesity and T2D.

Main Methods:

  • Development of a simplified surgical technique for sleeve gastrectomy in an animal model.

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Related Experiment Videos

Last Updated: Nov 28, 2025

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Published on: November 14, 2020

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A Murine Model of Vertical Sleeve Gastrectomy
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A Murine Model of Vertical Sleeve Gastrectomy

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  • Evaluation of the model's feasibility and reproducibility for preclinical research.
  • Assessment of key metabolic and body weight parameters post-surgery.

    • Main Results:

    • The developed surgical method is simple to perform with a low complication rate.
    • The animal model effectively replicates the body weight reduction and metabolic improvements observed in human bariatric surgery.
    • The model allows for detailed investigation of the physiological changes induced by sleeve gastrectomy.

    Conclusions:

    • This uncomplicated preclinical model offers a viable platform for studying bariatric surgery's effects on obesity and T2D.
    • Further research using this model can elucidate the mechanisms behind metabolic improvements after sleeve gastrectomy.
    • The model supports the advancement of obesity and T2D treatment strategies.