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Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Updated: Nov 28, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Top 10 priorities for future infertility research: an international consensus development study† ‡.

J M N Duffy^1,2, G D Adamson³, E Benson⁴

¹King's Fertility, Fetal Medicine Research Institute, London, UK.

Human Reproduction (Oxford, England)

|November 30, 2020

Summary

Future infertility research priorities were identified through international surveys and consensus meetings. These priorities address key areas including male and female infertility, assisted reproduction, and care access, guiding future research agendas.

Keywords:

Consensus science methods infertility modified Delphi method modified Nominal Group Technique reproductive medicine research priorities

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Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Area of Science:

Reproductive Medicine and Endocrinology
Public Health and Healthcare Policy

Background:

Numerous unanswered questions in infertility prevention, management, and consequences hinder improved patient care.
A significant gap exists in understanding and addressing the multifaceted aspects of fertility challenges.

Purpose of the Study:

To identify and prioritize future research needs in the field of infertility.
To establish a consensus-driven agenda for research in male infertility, female/unexplained infertility, medically assisted reproduction, and ethics/access to care.

Main Methods:

A multi-stage process involving international surveys, systematic reviews of guidelines, and consensus development meetings.
Utilized the modified nominal group technique with diverse stakeholders, including patients, healthcare professionals, and funders.
Data collated from 388 participants (initial survey) and 317 respondents (interim survey), culminating in a consensus meeting of 41 international participants.

Main Results:

Identified the top 10 research priorities across four key areas: male infertility, female and unexplained infertility, medically assisted reproduction, and ethics/access to care.
Priorities encompass prevention, treatment, and the longer-term impact of infertility, including psychological aspects and access in low-resource settings.
Highlighted the need for diverse research methodologies, from laboratory science to qualitative and quantitative population studies.

Conclusions:

The identified research priorities represent critical clinical needs as perceived by a broad range of stakeholders.
This consensus-driven agenda is expected to guide research funding organizations and researchers in shaping future infertility research.
Addressing these priorities will advance the field and improve care for individuals experiencing fertility problems.