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Percutaneous absorption: interfacial transfer kinetics.

W J Albery, J Hadgraft

    The Journal of Pharmacy and Pharmacology
    |February 1, 1979
    PubMed
    Summary
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    A novel rotating diffusion cell allows controlled solute transport through a filter, enabling measurement of interfacial transfer reaction rate constants. All eleven tested systems exhibited rate constants below 10(-4) ms-1.

    Area of Science:

    • Physical Chemistry
    • Chemical Engineering
    • Separation Science

    Background:

    • Interfacial transfer reactions are crucial in various chemical processes.
    • Measuring the kinetics of these reactions can be challenging due to transport limitations.
    • Existing methods may not adequately control solute transport for precise kinetic measurements.

    Purpose of the Study:

    • To introduce a new rotating diffusion cell design for studying solute transfer.
    • To demonstrate how controlled transport in this cell facilitates kinetic measurements.
    • To report rate constants for interfacial transfer reactions in eleven different systems.

    Main Methods:

    • A rotating diffusion cell with a filter filled with an organic phase was utilized.
    • Solute transport across the filter was controlled by the cell's rotation.

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  • The rate of solute transfer was analyzed to determine rate constants for interfacial reactions.

    • Main Results:

    • The rotating diffusion cell effectively controlled solute transport.
    • Rate constants for interfacial transfer reactions were successfully measured for eleven systems.
    • All determined rate constants were found to be less than 10(-4) ms-1.

    Conclusions:

    • The developed rotating diffusion cell is a viable tool for measuring interfacial transfer kinetics.
    • The controlled transport mechanism allows for accurate determination of rate constants.
    • The low rate constants observed suggest slow interfacial kinetics in the studied systems.