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3D Printing - Evaluating Particle Emissions of a 3D Printing Pen
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3D-printed Franz type diffusion cells.

B C Sil1, M P Alvarez2, Y Zhang2

  • 1London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.

International Journal of Cosmetic Science
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

3D-printed transparent Franz cells were developed for in vitro skin permeation studies. Incompatibilities were observed between tested active compounds and 3D-printed cells, impacting recovery rates.

Keywords:
In vitro3D printingFranz cellsPermeationResin

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Franz cells are standard for in vitro skin permeation analysis.
  • Cells must remain inert to permeants during testing.
  • 3D printing offers potential for custom, transparent cell fabrication.

Purpose of the Study:

  • To develop and manufacture transparent Franz-type diffusion cells using 3D printing.
  • To evaluate the performance of 3D-printed cells with model active compounds.
  • To identify critical 3D-printing parameters for cell fabrication.

Main Methods:

  • Transparent Franz cells were designed using CAD and fabricated with stereolithography 3D printers.
  • Acrylate-based resins (commercial and in-house synthesized) were used.
  • Comparative in vitro permeation studies were conducted using glass and 3D-printed cells with terbinafine hydrochloride, niacinamide, diclofenac free acid, and n-methyl paraben.

Main Results:

  • A decrease in compound recovery was observed in 3D-printed cells compared to glass cells.
  • n-methyl paraben showed the lowest recovery (53.8%) in 3D-printed cells.
  • Hydrophobic coatings did not prevent interactions between actives and 3D-printed cell materials.

Conclusions:

  • Transparent 3D-printed Franz cells are robust and leak-proof.
  • Incompatibilities exist between tested active compounds and available 3D-printing resins.
  • Further material development is needed for 3D-printed cells to ensure inertness in permeation studies.