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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Behçet's syndrome and ocular involvement: changes over time.

Chiara Posarelli1, Maria Novella Maglionico1, Rosaria Talarico2

  • 1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Italy.

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Summary

Ocular Behçet's syndrome management has improved with new diagnostics and biologics. Standardized definitions and outcome measures are still needed for optimal patient care.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Ocular involvement is a significant challenge in Behçet's syndrome, impacting both rheumatology and ophthalmology.
  • Recent advancements in diagnostics and biologic therapies have improved patient outcomes over the last two decades.
  • Lack of uniform definitions and diverse outcome measures hinder prompt and accurate management of ocular manifestations.

Purpose of the Study:

  • To review current evidence on the diagnosis and management of ocular involvement in Behçet's syndrome.
  • To provide a comprehensive summary for clinicians managing these complex cases.

Main Methods:

  • Literature review of recent studies on Behçet's syndrome and ocular manifestations.
  • Analysis of diagnostic tools and therapeutic strategies, including biologic drugs.
  • Synthesis of evidence regarding patient management protocols.

Main Results:

  • Biologic drugs have significantly enhanced treatment efficacy for ocular Behçet's syndrome.
  • New diagnostic tools aid in earlier and more accurate identification of the condition.
  • Despite progress, inconsistencies in definitions and outcome measures persist.

Conclusions:

  • Current evidence supports improved management of ocular Behçet's syndrome due to advancements.
  • Standardization of diagnostic criteria and outcome measures is crucial for future progress.
  • Multidisciplinary collaboration between rheumatologists and ophthalmologists is essential.