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Oral preparations with tunable dissolution behavior based on selective laser sintering technique
Yan Yang1, Yingying Xu1, Sainan Wei1
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
International Journal of Pharmaceutics
|November 30, 2020
Summary
Selective laser sintering (SLS) enables 3D printing of personalized oral medications. Tartrazine lake addition improved printability for non-yellow drugs, creating both immediate and sustained-release formulations.
Area of Science:
- Pharmaceutical Technology
- Additive Manufacturing
- Materials Science
Background:
- Selective laser sintering (SLS) is a 3D printing technique used for tissue engineering and implants.
- The application of SLS for oral solid preparations requires evaluating drug and excipient printability.
- Optimizing laser parameters and additives is crucial for successful pharmaceutical printing.
Purpose of the Study:
- To investigate the printability of common drugs and excipients using a 450 nm laser for SLS.
- To explore the mechanisms of SLS printing for crystalline and non-crystalline polymers.
- To develop and characterize immediate-release and sustained-release oral dosage forms using SLS.
Main Methods:
- Evaluation of SLS printability for various drugs and excipients with and without tartrazine lake as a photoabsorber.
- Analysis of printing mechanisms for crystalline and non-crystalline polymers.
- Optimization of laser energy density and layer thickness for printlet integrity.
- Formulation and characterization of ibuprofen immediate-release and metoprolol tartrate sustained-release tablets.
Main Results:
- Yellow drugs sintered directly; white drugs/excipients required tartrazine lake. Powder sintering and melting were observed for amorphous and crystalline polymers, respectively.
- Increased laser energy density improved efficiency but reduced accuracy; sintered layer thickness must exceed layer thickness.
- Optimized formulations produced immediate-release tablets with fast dissolution and sustained-release tablets with 12-hour release profiles.
- SLS printing did not alter the crystalline state of the drugs.
Conclusions:
- Selective laser sintering is a viable technique for producing personalized oral solid preparations with tailored release profiles.
- The addition of photoabsorbers like tartrazine lake significantly enhances SLS applicability for a wider range of pharmaceutical materials.
- SLS offers a promising platform for developing customized immediate-release and sustained-release drug delivery systems.
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