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Recent advances in tissue engineering scaffolds based on polyurethane and modified polyurethane.

Bushra Naureen1, A S M A Haseeb2, W J Basirun3

  • 1Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Materials Science & Engineering. C, Materials for Biological Applications
|December 1, 2020
PubMed
Summary

Polyurethane (PU) and modified PU (MPU) scaffolds show promise in tissue engineering for organ repair. This review highlights advances in PU/MPU scaffolds for regenerative medicine and biomedical applications.

Keywords:
Modified polyurethanePolyurethaneRegenerative medicineScaffoldTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Organ repair necessitates advanced solutions beyond traditional methods.
  • Tissue engineering (TE) offers effective tissue repair by combining cells, growth factors, and scaffolds.
  • Polyurethane (PU), a medical-grade synthetic polymer, is a key material in TE scaffolds due to its biocompatibility and tunable properties.

Purpose of the Study:

  • To review recent advancements in Polyurethane (PU) and modified PU (MPU) scaffolds for tissue engineering.
  • To highlight the biomedical applications of PU/MPU scaffolds in soft and hard tissue regeneration.
  • To discuss challenges and future directions for PU/MPU scaffold development.

Main Methods:

  • Review of literature on Polyurethane (PU) and modified Polyurethane (MPU) scaffolds.
  • Analysis of scaffold fabrication technologies and material modifications.
  • Evaluation of biomedical applications in soft and hard tissue engineering.

Main Results:

  • Polyurethane (PU) possesses excellent biocompatibility, biodegradability, and tunable properties for TE scaffolds.
  • Modified Polyurethane (MPU) scaffolds incorporate various bioactive agents (e.g., natural polymers, growth factors) to enhance functionality.
  • PU/MPU scaffolds demonstrate significant potential in regenerative medicine for diverse tissue repair applications.

Conclusions:

  • Polyurethane (PU) and its modified forms (MPU) are versatile biomaterials for advanced tissue engineering scaffolds.
  • Ongoing research focuses on optimizing PU/MPU scaffold properties like biodegradation and electroactivity for enhanced regenerative outcomes.
  • Future work should address challenges in scaffold functionalization and integration for broader biomedical applications.