Copper containing silicocarnotite bioceramic with improved mechanical strength and antibacterial activity

Copper is well known for its multifunctional biological effects including antibacterial and angiogenic activities, while silicon-containing bioceramic has proved to possess superior biological properties to hydroxyapatite (HA). In this work, CuO was introduced to silicocarnotite (Ca₅(PO₄)₂SiO₄, CPS) to simultaneously enhance its mechanical and antibacterial properties, and its cytocompatibility was also evaluated. Results showed that CuO could significantly facilitate the densification process of CPS bioceramic through liquid-phase sintering. The bending strength of CPS with the addition of 3.0 wt% CuO improved from 29.2 MPa to 63.4 MPa after sintered at 1200 °C. Moreover, Cu-CPS bioceramics demonstrated superior in vitro antibacterial property against both S. aureus and E. coli strains by destroying their membrane integrity, and the antibacterial activity augmented with CuO content. Meanwhile, the released Cu ions from Cu-CPS bioceramics could promote the proliferation of human umbilical vein endothelial cells (HUVECs), and the in vitro cytocompatibility exhibited concentration dependence on Cu ions. These suggest that Cu-CPS bioceramics might be promising candidates for bone tissue regeneration with an ability to prevent postoperative infections.