Blood group O is a risk factor for delayed post-polypectomy bleeding

Area of Science:

• Gastroenterology
• Hepatology
• Hematology

Background:

• The ABO blood group system is a well-established factor in various bleeding complications.
• However, its specific association with bleeding after endoscopic procedures remains under-investigated.

Purpose of the Study:

• To determine if blood group O increases the risk of delayed bleeding following colorectal endoscopic resection.

Main Methods:

• A retrospective observational study analyzed data from 8,625 patients undergoing colorectal endoscopic resection across four Japanese university hospitals between 2014 and 2017.
• Delayed bleeding was defined as requiring intervention within 28 days post-procedure.
• Multivariate logistic regression was used to assess the independent risk of blood group O.

Main Results:

• Delayed bleeding occurred in 2.96% of patients (255 cases).
• Patients with blood group O exhibited a significantly higher incidence of delayed bleeding compared to non-O groups (relative risk, 1.62).
• Blood group O was confirmed as an independent risk factor for delayed bleeding (adjusted odds ratio, 1.60).

Conclusions:

• Blood group O is associated with an elevated risk of delayed bleeding after colorectal endoscopic resection.
• Preoperative ABO blood group screening may enhance risk stratification for these patients.