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The development of specific IgG4 after immunotherapy with standardized extracts
N S Harris1, H S Rock, P T Leese
13M Diagnostic Systems, Santa Clara, CA 95051.
New England and Regional Allergy Proceedings
|November 1, 1987
Summary
Continuing immunotherapy after maintenance significantly reduced allergy symptoms and increased allergen-specific IgG4 antibodies. The 3M IgG4 FAST test accurately measured these antibody levels, supporting immunotherapy
Area of Science:
- Immunology
- Allergy Research
Background:
- Allergen immunotherapy (AIT) aims to desensitize patients to allergens.
- Monitoring treatment efficacy and immune response is crucial in AIT.
Purpose of the Study:
- To investigate the correlation between reduced allergic symptoms and allergen-specific IgG4 levels post-maintenance immunotherapy.
- To assess the utility of the 3M IgG4 FAST test in quantifying these antibodies.
Main Methods:
- Patients continued immunotherapy post-maintenance phase.
- Allergen-specific IgG4 levels were measured within one year.
- Symptom scores were recorded and analyzed.
- The 3M IgG4 FAST test was employed for antibody determination.
Main Results:
- Patients continuing immunotherapy showed significant symptom score reduction.
- All participants developing allergen-specific IgG4 antibodies post-maintenance.
- A positive correlation was observed between symptom reduction and increased specific IgG4.
Conclusions:
- Maintenance immunotherapy can lead to reduced allergic symptoms.
- Increased allergen-specific IgG4 antibodies accompany symptom improvement.
- The 3M IgG4 FAST test provides rapid and accurate measurement of specific IgG4.