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Lipidomics and Transcriptomics in Neurological Diseases
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Lipid profile: causal relationship on cognitive performance in multiple sclerosis?
Ana Laura Hernández-Ledesma1, Adriana Jheny Rodríguez-Méndez2, Lilia Susana Gallardo-Vidal3
1Laboratorio de Neuroinmunoendocrinología, Departamento de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel #200. Prados de la Capilla. CP 76170, Santiago de Querétaro, México.
Molecular Biology Reports
|December 1, 2020
Summary
Cognitive impairment (CI) is common in multiple sclerosis (MS). This study found that borderline lipid levels, including cholesterol, LDL, and triglycerides, correlate with decreased cognitive performance in MS patients.
Area of Science:
- Neurology
- Biochemistry
Background:
- Cognitive impairment (CI) is prevalent in multiple sclerosis (MS), though not routinely assessed.
- Neurological conditions can increase the risk of CI beyond typical aging.
Purpose of the Study:
- To investigate the association between lipid profiles and cognitive performance in individuals with MS.
- To explore potential links between specific lipid biomarkers and cognitive domains in MS.
Main Methods:
- Evaluated 20 patients with MS using the Montreal Cognitive Assessment (MoCA) for cognitive function.
- Analyzed correlations between lipid profile parameters (cholesterol, LDL, triglycerides) and MoCA scores.
Main Results:
- 85% of MS patients exhibited CI, primarily affecting memory recall and language.
- Significant correlations were found between MoCA total score and cholesterol/LDL, and attention domain with triglycerides/cholesterol.
- Borderline levels of triglycerides, LDL, and cholesterol were associated with reduced cognitive performance.
Conclusions:
- Lipid profiles may play a significant role in cognitive performance among individuals with MS.
- Potential mechanisms include neuroinflammation, synaptic alterations, and amyloid-beta metabolism.
- Further research is needed to establish optimal lipid levels for cognitive health in MS, particularly in Mexican populations.
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