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Bronchoconstriction: a potential missing link in airway remodelling

Michael J O'Sullivan¹, Thien-Khoi N Phung¹, Jin-Ah Park¹

¹Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, USA.

|December 1, 2020

Abstract:

In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood. As one of the important causes leading to airway remodelling, here we discuss the significance of mechanical forces that are produced in the narrowed airway during asthma exacerbation, as a driving force of airway remodelling. We cover in vitro, ex vivo and in vivo work in this field, and discuss up-to-date literature supporting the idea that bronchoconstriction may be the missing link in a comprehensive understanding of airway remodelling in asthma.

Keywords:

airway remodelling asthma bronchoconstriction mechanical stress

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