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Updated: Nov 28, 2025

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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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A Case-Based Review of Systemic Mastocytosis and Its Cutaneous Manifestations
Develyn Vetos1, Mandi Greenway Bietz2,3, B Joel Tjarks4,5
1University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Abstract:
Mastocytosis represents an uncommon spectrum of disorders where mast cells proliferate and accumulate in different organs and tissues throughout the body, most frequently affecting the skin. Here we present a case of systemic mastocytosis and review the manifestations of cutaneous and systemic mastocytosis to raise awareness and try to reduce the typical delay in diagnosis.
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