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Inflammaging in Endemic Areas for Infectious Diseases
Marina Andrade Batista1, Fernanda Calvo-Fortes1, Gabriela Silveira-Nunes2
1Programa de Pós Graduação em Nutrição e Saúde, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Frontiers in Immunology
|December 2, 2020
Summary
Healthy aging involves immunological remodeling, not just inflammation. Environmental factors influence biological markers of aging, impacting immune responses to infections and vaccination across diverse populations.
Area of Science:
- Gerontology
- Immunology
- Public Health
Background:
- Immunosenescence, characterized by inflammaging and immune defects, impairs responses to infections and vaccination in the elderly.
- Inflammaging, a chronic low-grade inflammation, is linked to age-related diseases and frailty.
- Some individuals exhibit healthy aging through immunological remodeling, escaping inflammaging's detrimental effects.
Purpose of the Study:
- To explore the biological markers of healthy aging.
- To investigate the interplay between inflammatory and remodeling processes in aging.
- To understand how environmental factors influence aging immune markers.
Main Methods:
- The study reviews existing literature on immunosenescence, inflammaging, and immunological remodeling.
- It analyzes the impact of environmental, cultural, and geographical settings on aging immune responses.
- Focuses on a non-westernized perspective of microbial contact and its outcomes.
Main Results:
- Healthy aging is associated with immunological remodeling, contrasting with inflammaging.
- Biological markers of healthy aging are debated and influenced by environmental context.
- Chronic infections may offer protection but accelerate immunosenescence in certain regions.
Conclusions:
- Healthy aging markers vary globally due to diverse environmental and microbial exposures.
- Inflammatory responses can be protective in high-infection regions but may accelerate aging.
- A non-westernized perspective is crucial for unbiased understanding of aging.
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